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In patients with severe colitis, however, particularly in the presence of additional risk factors (e.recent health-care contact, antibiotic use, hospitalization) concomitant treatment for presumed C.
Because it is often difficult to distinguish the effect of CDI independent from that of underlying IBD and because the data reporting worse outcomes in patients on combination immunosuppression and antibiotic therapy (153,154) have several limitations, we recommend that ongoing immunosuppression be continued at existing doses in IBD-CDI patients.
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